AstraZeneca adds to its treatments for blood cancer with $100M deal

AstraZeneca announced today (July 5) it has agreed to buy a company working on a cancer cure.

The company will hand over $100 million for TeneoTwo, Inc. in an upfront payment that will include its phase 1 clinical-stage CD19/CD3 T-cell engager, TNB-486, that is being evaluated in relapsed and refractory B-cell non-Hodgkin lymphoma.

With the deal, AstraZeneca is adding to its hematology pipeline, which already spans therapeutic modalities and mechanisms designed to address a wide-range of blood cancers.

New medicine

The company said by buying TNB-486, it hopes to accelerate the development of this potential new medicine for B-cell hematologic malignancies including the diffusion of large B-cell lymphoma and follicular lymphoma. It says this will help build on the success of its existing medicine Calquence (acalabrutinib) already being sold for the treatment of the disease.

TNB-486 belongs to a class of therapeutic antibodies known as T-cell engagers, which are emerging as a promising therapeutic approach in hematologic malignancies and solid tumors.

T-cell engagers are bispecific molecules that are engineered to redirect the immune system’s T-cells to recognize and kill cancer cells.

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