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First of its kind drug, to reverse effects of cocaine intoxication, awarded grant

An enzyme that efficiently degrades and metabolizes cocaine has been given a ‘cooperative agreement grant’ from the National Institute on Drug Abuse (NIDA) part of the National Institutes of Health.

The recombinant enzyme is a double-mutant cocaine esterase 200 mg intravenous (IV) solution and treats cocaine intoxication, which refers to the state of when cocaine has deleterious effects on several body systems – in particular cardiovascular.

Physiological effects

TNX-1300 demonstrated activity on reversing the physiological effects of IV cocaine challenge in people who use cocaine in a prior phase 2a randomized, double-blind, placebo-controlled clinical study.

Last year (2021), more than 24,900 people in the U.S. died from drug overdoses involving cocaine.

Seth Lederman, president and chief executive officer of Tonix Pharmaceuticals, said: “This grant award underscores the unmet need for safe and effective treatments for cocaine intoxication and validates the progress we have achieved to date with TNX-1300.

Serious issue

“Cocaine intoxication remains a serious issue in the U.S. where there is currently no specific pharmacotherapy indicated treatments.

The post First of its kind drug, to reverse effects of cocaine intoxication, awarded grant appeared first on Labiotech.eu.

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