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GSK Raises Eyebrows in Checkpoint Inhibitor Megadeal with iTeos

Analysts are abuzz over GSK’s co-development deal with immuno-oncology specialist iTeos Therapeutics earlier this month, wondering if it overpaid for the Belgian company’s next-generation checkpoint inhibitor. 

GSK’s oncology deal with iTeos earlier this month centered on an antibody drug that blocks an immune checkpoint called TIGIT. The candidate is currently in phase I testing for advanced solid tumors. The megadeal was worth €524M ($625M) upfront, as well as more than €1.2M ($1.4B) if developmental milestones are met. 

The hefty price tag reflects a recent spike in interest in TIGIT as an immune checkpoint target for cancer immunotherapies. Last month, US-based Agenus signed a similar deal with Bristol Myers Squibb for $200M (€168M) upfront.

TIGIT remains a speculative target today,” said Bertrand Delsuc, CEO and founder of the business intelligence firm Biotech Radar. “[I]t is likely GSK somewhat overpaid here.” 

However, Delsuc also observed that big cash is needed to secure deals in this increasingly competitive field.

The post GSK Raises Eyebrows in Checkpoint Inhibitor Megadeal with iTeos appeared first on Labiotech.eu.

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