Optimizing Bioproduction Using Transient Expression Systems

During drug development, biologics often fail to transition from the preclinical to the clinical stage, resulting in huge losses in time and money. We explore how choosing the right expression system and optimizing a method known as transient protein expression may offer a potential solution. 

Bioproduction is the use of living systems to produce complex therapeutic drugs such as antibodies or enzymes. These living systems, which include bacterial, yeast, and mammalian cells, are referred to as expression hosts, and the resulting drug, a biologic. 

During bioproduction, a plasmid — an engineered genetic construct — is delivered to the host cell. The plasmid contains instructions on how to translate the genetic information using the host’s own machinery, and enabling successful protein production.

The entire set-up, consisting of the host cells, plasmid, and conditions used to enable bioproduction, is known as a protein expression system.

The importance of choosing an optimal expression system

The drug discovery and development process is often lengthy, spanning over 10 years on average.

The post Optimizing Bioproduction Using Transient Expression Systems appeared first on Labiotech.eu.

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