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Poxel publishes ALD studies

Two preclinical articles have been published in different journals for treatments being developed by French biopharmaceutical company, Poxel.

Poxel develops treatments for chronic, serious diseases with metabolic pathophysiology including non-alcoholic steatohepatitis (NASH) and rare metabolic disorders. The articles have been about genetic disease X-Linked Adrenoleukodystrophy (ALD) and molecules PXL065 and PXL770.

These molecules have separate and distinct mechanisms of action: PXL065 is a novel, proprietary deuterium-stabilized R-stereoisomer of pioglitazone which exerts effects via multiple non-genomic pathways engaged by thiazolidinedione molecules; PXL770 is a novel, first-in-class direct adenosine monophosphate-activated protein kinase (AMPK) activator.

Biomarker studies

Both compounds will soon enter into phase 2a clinical proof-of-concept (POC) biomarker studies in ALD patients with adrenomyeloneuropathy (AMN) as soon as possible, subject to financing.

An article on PXL065 has been published in The Journal of Inherited Metabolic Disease (“JIMD”), called “Therapeutic potential of deuterium-stabilized (R)-pioglitazone – PXL065 – for X-linked adrenoleukodystrophy”.

An article on PXL770 has been published in The Journal of Pharmacology and Experimental Therapeutics (“JPET”),

The post Poxel publishes ALD studies appeared first on Labiotech.eu.

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